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AndreyKhoviakov21 декабря 2023 г.Читать далееThis would seem to be a relatively straightforward task: sequence the genomes of a few thousand centenarians and see which individual genes or gene variants stand out as being more prevalent among this population than in the general population. Those would be your candidate genes. But when researchers did this, examining thousands of individuals via genome-wide association studies, they came up almost empty-handed. These individuals appeared to have very little in common with one another genetically. And their longevity may be due to dumb luck after all.
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AndreyKhoviakov21 декабря 2023 г.This is part of why I place so much importance on taking a detailed family history from my patients: I need to know when your relatives died and why. What are your likely “icebergs,” genetically speaking?
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AndreyKhoviakov21 декабря 2023 г.Frenchwoman Jeanne Calment, who once joked, “I’ve only ever had one wrinkle, and I’m sitting on it.”
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AndreyKhoviakov21 декабря 2023 г.as the great philosopher Mike Tyson once put it, “Everyone has a plan until they get punched in the mouth.”
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AndreyKhoviakov21 декабря 2023 г.This means that we have delayed your death without significantly improving your quality of life—something at which Medicine 2.0 is quite adept. This is the Marginal Decade that most of us can expect, in our current system.
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AndreyKhoviakov21 декабря 2023 г.In Medicine 2.0, you are a passenger on the ship, being carried along somewhat passively. Medicine 3.0 demands much more from you, the patient: You must be well informed, medically literate to a reasonable degree, clear-eyed about your goals, and cognizant of the true nature of risk.
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AndreyKhoviakov21 декабря 2023 г.First, Medicine 3.0 places a far greater emphasis on prevention than treatment.
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AndreyKhoviakov21 декабря 2023 г.The trouble began with Hippocrates. Most people are familiar with the ancient Greek’s famous dictum: “First, do no harm.” It succinctly states the physician’s primary responsibility, which is to not kill our patients or do anything that might make their condition worse instead of better. Makes sense. There are only three problems with this: (a) Hippocrates never actually said these words,[*1] (b) it’s sanctimonious bullshit, and (c) it’s unhelpful on multiple levels.
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AndreyKhoviakov21 декабря 2023 г.In late 2007, after six months of round-the-clock work, we had a big meeting with the top brass of our client, a major US bank. Normally, my boss, as the senior partner on the project, would have handled the presentation. But instead he picked me. “Based on your previous career choice,” he said, “I suspect you are better prepared to deliver truly horrible news to people.”
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